Vectis
Drug Safety Intelligence · Oxford ✓ Validated on independent RNA-seq
Vectis
Biosciences

Mechanistic drug safety prediction from molecular structure. Built for novel drug classes where no clinical history exists.

✓ RNA-seq validated 22 drugs · 8 mechanism classes PROTAC · CELMoD · IMiD
Analysing
Running mechanistic safety pipeline…
1
Molecular docking
Vina · 143 protein structures
2
Signalling cascade
OmniPath · 1,516 genes · 6 cell types
3
GNN refinement
LINCS-trained · log₂FC per gene
4
Adverse event classification
21 classifiers · FDA-label trained
Signal propagation
Signalling network
Upregulated
Downregulated
Drug target
#ProteinConfidenceEffect